An aggregate of microtubules that move chromosomes during cell division.
During prophase:
Spindle fibers form at opposite poles of the cell.
During metaphase:
Spindle fibers extend from the cell poles to align chromosomes at the metaphase plate.
During anaphase:
Spindle fibers pull the chromatids toward the spindle poles, and lengthen and elongate the cell.
In biology the genome of an organism is its whole hereditary information and is encoded in the DNA (or, for some viruses, RNA). This includes both the genes and the non-coding sequences of the DNA. The term was coined in 1920 by Hans Winkler, Professor of Botany at the University of Hamburg, Germany, as a portmanteau of the words gene and chromosome.[1]
More precisely, the genome of an organism is a complete DNA sequence of one set of chromosomes; for example, one of the two sets that a diploid individual carries in every somatic cell. The term genome can be applied specifically to mean the complete set of nuclear DNA (i.e., the "nuclear genome") but can also be applied to organelles that contain their own DNA, as with the mitochondrial genome or the chloroplast genome. When people say that the genome of a sexually reproducing species has been "sequenced," typically they are referring to a determination of the sequences of one set of autosomes and one of each type of sex chromosome, which together represent both of the possible sexes. Even in species that exist in only one sex, what is described as "a genome sequence" may be a composite from the chromosomes of various individuals. In general use, the phrase "genetic makeup" is sometimes used conversationally to mean the genome of a particular individual or organism. The study of the global properties of genomes of related organisms is usually referred to as genomics, which distinguishes it from genetics which generally studies the properties of single genes or groups of genes.
Euchromatin is a lightly packed form of chromatin that is rich in gene concentration, and is often (but not always) under active transcription. Unlike heterochromatin, it is found in both eukaryotes and prokaryotes
Structure
The structure of euchromatin is reminiscient of an unfolded set of beads along a string, where those beads represent nucleosomes. Nucleosomes consist of eight proteins known as histones, with approximately 146 base pairs of DNA wound around them; in euchromatin this wrapping is loose so that the raw DNA may be accessed. Each core histone possesses a `tail' structure which can vary in several ways; it is thought that these variations act as "master control switches" which determine the overall arrangement of the chromatin. In particular, it is believed that the presence of methylated lysine 4 on the histone tails acts as a general marker for euchromatin.
[edit] Appearance
Euchromatin generally appears as light-colored bands when stained in GTG banding and observed under an optical microscope; in contrast to heterochromatin, which stains darkly. This lighter staining is due to the less compact structure of euchromatin. It should be noted that in prokaryotes, euchromatin is the only form of chromatin present; this indicates that the heterochromatin structure evolved later along with the nucleus, possibly as a mechanism to handle increasing genome size and therefore a decrease in safety/manageability.
[edit] Function
Euchromatin participates in the active transcription of DNA to mRNA products. The unfolded structure allows gene regulatory proteins and RNA polymerase complexes to bind to the DNA sequence, which can then initiate the transcription process. Not all euchromatin is necessarily transcribed, but in general that which is not is transformed into heterochromatin to protect the genes while they are not in use. There is therefore a direct link to how actively productive a cell is and the amount of euchromatin that can be found in its nucleus. It is thought that the cell uses transformation from euchromatin into heterochromatin as a method of controlling gene expression and replication, since such processes behave differently on densely compacted chromatin- this is known as the `accessibility hypothesis'.
The literal definition of the term macromolecule implies any large molecule. In the context of science and engineering, the term may be applied to conventional polymers and biopolymers (such as DNA) as well as non-polymeric molecules with large molecular mass such as lipids or macrocycles. However, other large networks of atoms, such as metallic covalent networks or fullerenes, are not generally described as macromolecules. The term macromolecule was coined by Nobel laureate Hermann Staudinger in the 1920s.
Down syndrome or trisomy 21 (Down's Syndrome in British English[1]) is a genetic disorder caused by the presence of all or part of an extra 21st chromosome. It is named after John Langdon Down, the British doctor who described it in 1866. The condition is characterized by a combination of major and minor differences in body structure. Often Down syndrome is associated with some impairment of cognitive ability and physical growth as well as facial appearance. Down syndrome is usually identified at birth.
Individuals with Down syndrome can have a lower than average cognitive ability, often ranging from mild to moderate mental retardation. Developmental disabilities often manifest as a tendency toward concrete thinking or naïveté. A small number have severe to profound mental retardation. The incidence of Down syndrome is estimated at 1 per 800 to 1,000 births.
Many of the common physical features of Down syndrome also appear in people with a standard set of chromosomes. They include a single transverse palmar crease (a single instead of a double crease across one or both palms), an almond shape to the eyes caused by an epicanthic fold of the eyelid, shorter limbs, poor muscle tone, and protruding tongue. Health concerns for individuals with Down syndrome include a higher risk for congenital heart defects, gastroesophageal reflux disease, recurrent ear infections, obstructive sleep apnea, and thyroid dysfunctions.
Early childhood intervention, screening for common problems, medical treatment where indicated, a conducive family environment, and vocational training can improve the overall development of children with Down syndrome. Although some of the physical genetic limitations of Down syndrome cannot be overcome, education and proper care will improve quality of life.[2]
Protein synthesis is the creation of proteins using DNA and RNA.Biological and artificial methods for creation of proteins differ significantly.
For biological protein synthesis, see protein biosynthesis.
For artificial protein synthesis, see peptide synthesis.
Ribonucleic acid (RNA) is a nucleic acid polymer consisting of nucleotide monomers, that acts as a messenger between DNA and ribosomes, and that is also responsible for making proteins out of amino acids.[1] RNA polynucleotides contain ribose sugars and predominantly uracil unlike deoxyribonucleic acid (DNA), which contains deoxyribose and predominantly thymine. It is transcribed (synthesized) from DNA by enzymes called RNA polymerases and further processed by other enzymes. RNA serves as the template for translation of genes into proteins, transferring amino acids to the ribosome to form proteins, and also translating the transcript into proteins.
Nucleic acids were discovered in 1868 (some sources indicate 1869) by Johann Friedrich Miescher (1844-1895), who called the material 'nuclein' since it was found in the nucleus. It was later discovered that prokaryotic cells, which do not have a nucleus, also contain nucleic acids. The role of RNA in protein synthesis had been suspected since 1939, based on experiments carried out by Torbjörn Caspersson, Jean Brachet and Jack Schultz. Hubert Chantrenne elucidated the messenger role played by RNA in the synthesis of proteins in ribosome. The sequence of the 77 nucleotides of a yeast RNA was found by Robert W. Holley in 1964, winning Holley the 1968 Nobel Prize for Medicine. In 1976, Walter Fiers and his team at the University of Ghent determined the complete nucleotide sequence of bacteriophage MS2-RNA.[1]
A plasmid is a DNA molecule separate from the chromosomal DNA and capable of autonomous replication. It is typically circular and double-stranded. It usually occurs in bacteria, sometimes in eukaryotic organisms (e.g., the 2-micrometre-ring in Saccharomyces cerevisiae). Size of plasmids varies from 1 to over 400 kilobase pairs (kbp). There may be one copy, for large plasmids, to hundreds of copies of the same plasmid in a single cell, or even thousands of copies, for certain artificial plasmids selected for high copy number (such as the pUC series of plasmids). Plasmids can be part of the mobilome, since they are often associated with conjugation, a mechanism of horizontal gene transfer.
The term plasmid was first introduced by the American molecular biologist Joshua Lederberg in 1952
Lamarckism or Lamarckian evolution is a theory put forward by the French biologist Jean-Baptiste Pierre Antoine de Monet, Chevalier de Lamarck, based on heritability of acquired characteristics, the once widely accepted idea that an organism can pass on characteristics that it acquired during its lifetime to its offspring.
Theories of Evolution
Based on Essentialism:
Transmutationism (saltationism)
Transformationism
Orthogenesis
Lamarckism
Based on Population biology:
Darwinian evolution
It proposed that individual efforts during the lifetime of the organisms were the main mechanism driving species to adaptation, as they supposedly would acquire adaptative changes and pass them on to offspring. After publication of Charles Darwin's theory of natural selection, the importance of individual efforts in the generation of adaptation was considerably diminished. Later, Mendelian genetics supplanted the notion of inheritance of acquired traits, eventually leading to the development of the modern evolutionary synthesis, and the general abandonment of the Lamarckian theory of evolution in biology. In a wider context, Lamarckism is of use when examining the evolution of cultures and ideas, and is related to the theory of Memetics.
While enormously popular during the early 19th century as an explanation for the complexity observed in living systems, Lamarckism's acceptance within the scientific community dwindled following the dawn of the Darwinian synthesis, currently universally accepted as an explanation for the adaptive complexity of all life forms.
Traditionally in medicine, a vector is an organism that does not cause disease itself but which spreads infection by conveying pathogens from one host to another. Species of mosquito, for example, serve as vectors for the deadly disease malaria. This is generally referred to as a "biological vector" in epidemiology and in common speech.
In gene therapy, a virus itself may serve as a vector, if it has been re-engineered and is used to deliver a gene to its target cell. A "vector" in this sense is a vehicle for delivering genetic material such as DNA to a cell.
There is a possibility for confusion between the use of "vector" in gene therapy and its use in molecular biology more generally. Some transformation technologies, such as lipofectamine, enable the direct delivery of a DNA construct as therapy in a tissue. In such a situation, a plasmid vector may be regarded as serving as its own gene-therapy vector. When a speaker calls it "a vector," they may be referring to either of its vector aspects or often both.
A unit of selection is a biological entity within the hierarchy of biological organisation (e.g. genes, cells, individuals, groups, species) that is subject to natural selection. For several decades there has been intense debate among evolutionary biologists about the extent to which evolution has been shaped by selective pressures acting at these different levels. This debate has been as much about what it means to be a unit of selection as it has about the relative importance of the units themselves, i.e., is it group or individual selection that has driven the evolution of altruism? When it is noted that altruism reduces the fitness of individuals, it is difficult to see how altruism has evolved within the context of Darwinian selection acting on individuals; see Kin selection.
Gene therapy is the insertion of genes into an individual's cells and tissues to treat a disease, and hereditary diseases in which a defective mutant allele is replaced with a functional one. Although the technology is still in its infancy, it has been used with some success. Antisense therapy is not strictly a form of gene therapy, but is a genetically-mediated therapy and is often considered together with other methods.
The gracile australopithecines (members of the genus Australopithecus) (Latin australis "of the south", Greek pithekos "ape") are a group of extinct hominids that are closely related to humans.
The Foraminifera, or forams for short, are a large group of amoeboid protists with reticulating pseudopods, fine strands of cytoplasm that branch and merge to form a dynamic net.[1] They typically produce a shell, or test, which can have either one or multiple chambers, some becoming quite elaborate in structure.[2] About 275,000 species are recognized, both living and fossil[citation needed]. They are usually less than 1 mm in size, but some are much larger, and the largest recorded specimen reached 19 cm[citation needed].
Although as yet unsupported by morphological correlates, molecular data strongly suggest that Foraminifera are closely related to the Cercozoa and Radiolaria, both of which also include amoeboids with complex shells; these three groups make up the Rhizaria[3] However, the exact relationships of the forams to the other groups and to one another are still not entirely clear.
Deoxyribonucleic acid, or DNA is a nucleic acid molecule that contains the genetic instructions used in the development and functioning of all living organisms. The main role of DNA is the long-term storage of information and it is often compared to a set of blueprints, since DNA contains the instructions needed to construct other components of cells, such as proteins and RNA molecules. The DNA segments that carry this genetic information are called genes, but other DNA sequences have structural purposes, or are involved in regulating the use of this genetic information.
Chemically, DNA is a long polymer of simple units called nucleotides, which are held together by a backbone made of alternating sugars and phosphate groups. Attached to each sugar is one of four types of molecules called bases. It is the sequence of these four bases along the backbone that encodes information. This information is read using the genetic code, which specifies the sequence of the amino acids within proteins. The code is read by copying stretches of DNA into the related nucleic acid RNA, in a process called transcription. Most of these RNA molecules are used to synthesize proteins, but others are used directly in structures such as ribosomes and spliceosomes.
Within cells, DNA is organized into structures called chromosomes and the set of chromosomes within a cell make up a genome. These chromosomes are duplicated before cells divide, in a process called DNA replication. Eukaryotic organisms such as animals, plants, and fungi store their DNA inside the cell nucleus, while in prokaryotes such as bacteria it is found in the cell's cytoplasm. Within the chromosomes, chromatin proteins such as histones compact and organize DNA, which helps control its interactions with other proteins and thereby control which genes are transcribed.
Arthropods (Phylum Arthropoda, from the Greek ἄρθρον, meaning joint and ποδός, meaning foot) are the largest phylum of animals and include the insects, arachnids, crustaceans, and others. More than 80% of described living animal species are arthropods [1], with over a million modern species described and a fossil record reaching back to the late proterozoic era. Arthropods are common throughout marine, freshwater, terrestrial, and even aerial environments, as well as including various symbiotic and parasitic forms. They range in size from microscopic plankton (~¼ mm) up to forms several metres long. The largest living arthropod is the Japanese spider crab, with a leg span up to 3½ m (12 ft), and some prehistoric arthropods were even larger, such as Pterygotus and Arthropleura.
Arthropods are characterised by the possession of a segmented body with appendages on each segment. They have a dorsal heart and a ventral nervous system. All arthropods are covered by a hard exoskeleton made of chitin, a polysaccharide, which provides physical protection and resistance to desiccation. Periodically, an arthropod sheds this covering when it moults.
Global warming is the increase in the average temperature of the Earth's near-surface air and oceans in recent decades and its projected continuation.
Global average air temperature near the Earth's surface rose 0.74 ± 0.18 °C (1.3 ± 0.32 °F) during the past century. The Intergovernmental Panel on Climate Change (IPCC) concludes, "most of the observed increase in globally averaged temperatures since the mid-20th century is very likely due to the observed increase in anthropogenic greenhouse gas concentrations,"[1] which leads to warming of the surface and lower atmosphere by increasing the greenhouse effect. Natural phenomena such as solar variation combined with volcanoes have probably had a small warming effect from pre-industrial times to 1950, but a cooling effect since 1950. The basic conclusions have been endorsed by at least 30 scientific societies and academies of science, including all of the national academies of science of the major industrialized countries. The American Association of Petroleum Geologists is the only scientific society that rejects these conclusions,[2][3][4] although a comparatively small number of individual scientists do disagree with parts of them.
Climate models referenced by the IPCC project that global surface temperatures are likely to increase by 1.1 to 6.4 °C (2.0 to 11.5 °F) between 1990 and 2100.[1] The range of values reflects the use of differing scenarios of future greenhouse gas emissions and results of models with differences in climate sensitivity. Although most studies focus on the period up to 2100, warming and sea level rise are expected to continue for more than a millennium even if greenhouse gas levels are stabilized.[1] This reflects the large heat capacity of the oceans.
An increase in global temperatures can in turn cause other changes, including sea level rise, and changes in the amount and pattern of precipitation. There may also be changes in the frequency and intensity of extreme weather events, though it is difficult to connect specific events to global warming. Other effects may include changes in agricultural yields, glacier retreat, reduced summer streamflows, species extinctions and increases in the ranges of disease vectors.
Remaining scientific uncertainties include the exact degree of climate change expected in the future, and how changes will vary from region to region around the globe. There is ongoing political and public debate regarding what, if any, action should be taken to reduce or reverse future warming or to adapt to its expected consequences. Most national governments have signed and ratified the Kyoto Protocol aimed at combating greenhouse gas emissions.