why telomerase activity is required in eukaryotic DNA replication?

Question

why telomerase activity is required in eukaryotic DNA replication?

Answer 1

Telomerase is an enzyme, thus it is also a protein, since enzymes are proteins.



Telomerase is vital because it actually extends the dna. If telomerase didn't exist, then after DNA replication, the DNA would get shorter and shorter, and you would lose vital information in the form of gene code. Telomerase basically prevents the DNA from getting shorter and shorter, by adding more nucleotides to the end of the string.



If your DNA got shorter and shorter, the cell would die, and eventually you would to. This is one theory on how we age.

Answer 2

THE DIFFERENCE BETWEEN TELOMERES AND TELOMERASE AND THE ROLE THEY PLAY IN AGING.



In 1971 Dr. Alexey M. Olovnikov published a theory in which he first formulated the DNA end (telomeres) replication problem and explained how it could be solved. The solution to this problem also provided an explanation for the Hayflick Limit (the 125 year ceiling on the human lifespan), which underpins the discovery of in vitro and in vivo cell senescence (deterioration). Telomeres are a repeating DNA sequence of 6 RNA/DNA pairings, (A-T,A-T,T-A, C-G,C-G,C-G). When a cell divides, the new DNA cannot complete it's final pairing thus telomeres get shorter with each cell division. We are conceived with 15,000 pairs of telomeres, are born with 10,000 pairs and generaly die when we hit 5000 pairs. Telomerase is an enzyme which when activated in the cell provides a sort of "platform" as it where, so that the new DNA strand is able to complete. The telomerase enzyme attaches to the end of the chromosome; complementary bases to the RNA template are added on the 3' end of the DNA strand. Once the lagging strand is elongated by telomerase, DNA polymerase can add the complementary nucleotides to the ends of the chromosomes and the telomeres can finally be replicated.

. It used to be thought that telomerase production promoted cancer since cancer cells themselves have the telomerase enzyme turned on, however the latest research by Dr. William Andrews, the discoverer of the telomerase enzyme, has shown the opposite to be true. Ctiating telomerase in healthy cells around a tumer will cause a cancerous tumor to reduce. This is due mainly to boost in the bodies natural immune functions. For a free 30 day seminar on telomeres try https://christopher-george.leadpages.net/telomere-report/

Answer 3

You see, when a Dna is replicated on the antiparallel strand from3' to 5' end the okazaki fragments are required. after the replication is over then the distal okazaki fragments are removed. this removal creates unreplicated strands and hence shortening of DNA called genomic senescence. Telomerase enzyme recovers this lost part and prevents genomic degradation.